Premier Research Labs
Tranquinol
A calming botanical formula combining passionflower, valerian root, and L-theanine to ease stress, quiet mental chatter, and support healthy sleep onset without next-day grogginess.
Serving Size: 3 capsules
Key Ingredients
Malate form of magnesium that crosses the blood-brain barrier effectively. Supports GABA synthesis, muscle relaxation, and nervous system calming. Malic acid additionally supports mitochondrial energy production.
Clinically proven to increase alpha brainwave activity — the state of calm alertness — within 30-60 minutes. Increases GABA, serotonin, and dopamine. Reduces anxiety without sedation.
The most clinically studied saffron extract. Multiple double-blind RCTs demonstrate significant reduction in anxiety, improvement in mood, and better sleep quality. Crocins in saffron inhibit serotonin reuptake.
Passionflower increases GABA by inhibiting its reuptake — providing anxiolytic effects comparable to low-dose benzodiazepines without dependency risk. Lemon balm inhibits GABA-transaminase and has significant anti-anxiety evidence.
Valerian binds GABA-A receptors to promote sleep onset and reduce sleep latency. Lavender (linalool) has robust clinical evidence for reducing anxiety and improving sleep quality.
Honokiol and magnolol are potent GABA-A receptor agonists and cortisol modulators. Highly bioavailable and cross the blood-brain barrier rapidly to reduce anxiety and promote sleep.
Health Benefits
- Promotes calm relaxation without sedation or grogginess
- Supports healthy sleep onset and sleep architecture
- Clinically studied reduction in anxiety and mental tension
- GABA support through multiple independent pathways
- Non-habit-forming and safe for long-term use
- Mood support through serotonin and dopamine modulation